报告时间: 2010年8月3日，星期二，上午9：30

　　报告地点：生物楼学术报告厅

　　报告人：Yingming Zhao

　　Ben May Department for Cancer Research, The University of Chicago, USA

　　报告人摘要:

　　Extensive studies in histones and p53 suggest that these proteins can be modified by an array of protein post-translational modifications (PTMs), most of which are correlated with important biological functions. Nevertheless, PTM types and their sites in other proteins remain largely unknown, except several widely studied ones. The information deficiency suggests an urgent need for reliable technology for characterization of all the PTMs in a protein and for their dynamic studies. To this end, we recently developed an unrestrictive protein sequence alignment algorithm, PTMap, and used it in conjunction with mass spectrometry for accurate identification of all the possible PTMs, known or undescribed ones. We have used the algorithm to identify novel PTMs, to discover common in vitro protein modifications, to study PTM cross-talks, and to study protein mutations. In this presentation, applications of such mass spectrometry-based proteomics technologies will be discussed.

　　主办单位：大连化物所生物技术部&中国科学院分离分析化学重点实验室